▷▷▷[pleural mesothelioma] - Prognosis, Life Expectancy & Treatment Info

▷▷▷[pleural mesothelioma] - Prognosis, Life Expectancy & Treatment Info!!

Pleural Mesothelioma

Pleural mesothelioma is the most common of all types of mesothelioma. The manipulation of the soft tissues around the lungs known as a chest or pleural membrane. Mesothelioma cancer can develop in various parts of the body, but they come from the pleura in about 75 percent of all cases. Anyway cancers in the mesothelium, a membrane that the tissue of various organs and body cavities protects.

Pleural mesothelioma is usually caused by occupational exposure to asbestos fibers in the air. Because this exposure is often male-dominated industry, about 80 percent of all mesothelioma patients are men. When inhaled into the lungs, asbestos fibers acicular migrate to the pleural membrane, where the body does not easily get rid of them. The fibers irritate the pleura, which can lead to chronic inflammation and scarring. In rare cases cause pleural mesothelioma.

Over a longer period - usually three or more decades - asbestos causes genetic changes in pleural cells. When cells become cancerous, they begin to divide uncontrollably, form tumors that reduces lung capacity and generates the accumulation of excess fluid from the pleural layers.

The Anatomy and Function of the Pleura

 The pleura has two layers of protection and support for the lungs and other vital structures in the breast care. It also produces a lubricating fluid to the cavity between the two layers by expansion and contraction of the lungs and breathing. The outer layer, parietal pleura, lines the chest cavity. The inner layer or layer that is visceral lungs.

It's not uncommon for mesothelioma affects both layers of the pleura. Pleural mesothelioma usually develops in one layer of the pleura and rapidly invades surrounding communities, such as the diaphragm, chest wall and lungs. If the cancer to the lymph nodes, can metastasize or spread to distant sites in the body.

Pleural Mesothelioma Symptoms

When asbestos fibers may be normal cells become malignant pleural pleural membrane shape and gradually thickens. The thickening can pleural effusion, excessive accumulation of fluid in the space between the layers of the pleura. This fluid on the lungs, causing chest pain, and the absence of normal breathing. These complications are largely responsible for the symptoms of pleural mesothelioma include:

          -  Persistent dry cough or rough
          -  Coughing up blood (hemoptysis)
          -  Shortness of breath (dyspnea)
          -  Pain in the lower back or chest
          -  painful breathing

          -  The development of lumps in the breast skin
          -  Difficulty swallowing (dysphagia)
          -  Night sweats or fever
          -  unexplained weight loss
          -  fatigue

Even if someone at a later stage of weight loss and fatigue experienced pleural less than 30 percent of patients with these symptoms for diagnosis or in the early stages of the disease. During an initial consultation with their doctors, more than 60 percent of patients, chest pain and shortness of breath due to pleural effusion spiritual experience.

Pleural Mesothelioma Diagnosis

In other forms of the disease, pleural mesothelioma can be difficult to diagnose, even for experts. Symptoms usually occur long after the initial exposure to asbestos. And since many respiratory diseases cause similar symptoms, pleural mesothelioma is often confused with less deadly diseases such as influenza and pneumonia. Moreover, it is difficult for the physician to distinguish between pleural mesothelioma and adenocarcinoma, a common form of lung cancer.

Diagnostic Imaging

A diagnosis of mesothelioma may be achieved in part based on symptoms, but other diagnostic tests is often necessary to confirm the presence of cancer. For the best treatment options and patient's perspective, early diagnosis is crucial. After a review of medical and occupational history and physical examination, patients typically undergo imaging studies to identify potential tumors. Conventional radiographs may reveal pleural effusion and pleural-based mass in some cases, but CT images are often more advanced or asbestos.

X-rays or CT-Scans are often
used to diagnose pleural mesothelioma.

With the introduction of PET in the early 1960s, doctors could better distinguish benign (non-cancerous) or malignant pleural tumors. In addition, PET can detect lymph node cancer spread scanners often miss an advantage that is particularly useful for organizing mesothelioma. A combination of two promising technique, called PET-CT, born 2000. Some experts claim that PET-CT can accurately patient's response to chemotherapy as PET and CT scans administered alone to predict, but further research should be conducted to confirm with certainty.

Cytology and biopsy

Cytologies and biopses help diagnose
mesothelioma with higher confidence.

While recent developments in imaging significantly improved the diagnostic process, more invasive procedures are usually needed mesothelioma diagnosis with a high degree of confidence. This procedure is thoracentesis, in which a hollow needle into the lungs, pleural fluid collection. The cytological examination of the cell samples were inspected physicians find biomarkers that indicate the presence of cancer, such as epithelial membrane antigen (EMA), calretinin and WT1. Experienced doctors can use to cytological diagnosis in 80 percent of mesothelioma cases.

But sometimes, the results are unclear or pleural completely absent. In these cases, doctors perform biopsies for pleural tissue samples to obtain. Stains dye was added to the samples to help doctors to visualize cell structures. A popular method of fine needle aspiration biopsy, but the researchers found that thoracoscopy is much more likely to yield positive results. Thoracoscopic biopsy produced a diagnosis in 98 percent of patients with mesothelioma. The current gold standard for the diagnosis of pleural mesothelioma tissue samples must be examined under an electron colorful. If a series of tests or biopsies can confirm the presence of mesothelioma, the doctor develop a treatment plan based on the results.

Treatment Pleural Mesothelioma

Historical mesothelioma doctors treated with conventional cancer treatments such as surgery, chemotherapy and radiotherapy. Depending on the distance between mesothelioma patient is, these therapies have both a curative or palliative. Even patients with pleural mesothelioma is rarely diagnosed early enough to benefit from curative surgery, there are many palliative treatments that can relieve painful symptoms, improve quality of life and significantly prolong survival. The researchers also evaluates several alternative treatments such as immunotherapy and gene therapy, which once developed a day be standard mesothelioma treatment.

 Surgery for pleural mesothelioma

Surgery continues to serve as a primary treatment for patients with pleural mesothelioma. A common method is pleurectomy / scaling (P / D) which is the surgical removal of the tumor of the pleura and influenced. A more aggressive surgical options, extrapleural pneumonectomy (EPP) is designed to safely remove an entire lung, the diaphragm and the pericardium, a protective membrane lining the heart. Only a fraction of patients have pulmonary function well enough to qualify for the EPP, and a large, multi-function analysis concluded that P / D gives better results with less risk EPP.

Chemotherapy for Pleural Mesothelioma

One of the most common treatments for mesothelioma palliative chemotherapy, which uses one or more drugs to kill cancer cells and shrink tumors. Although recent advances have improved the patients' response to chemotherapy, were successful in general low. About 15 to 20 percent of mesothelioma patients experience a significant reduction in tumor size after chemotherapy.

Showed mesothelioma clinical trials combining several chemotherapy in a single treatment potential. A multicenter phase 3 studies, for example, found that the combination of pemetrexed and cisplatin survival prolonged Median overall patients 2.8 months compared to patients treated with cisplatin alone. 41 percent of patients treated with pemetrexed / cisplatin regimen experienced tumor shrinkage of at least 50 percent. Even a combination of chemotherapy pleural mesothelioma treatments have not yet been discovered, it is an important goal for scientists is currently involved in several clinical trials.

Radiation therapy for pleural mesothelioma

Pleural are often resistant to radiation. In this treatment destroys the doctor who administers radiation cancer target cells and reduce tumor size. Although this is a poor curative options, radiotherapy can be very effective for the treatment of symptoms such as chest pain. One of radiotherapy techniques, the most successful is called intensity modulated radiation therapy. Usually given to patients with low-dose intervals after radical surgery PPE avoid this technique a recurrence of cancer in many cases. Although effective for preventing cancer recurrence in the areas where the radiation is administered, spread to distant locations is still a challenge.

Multimodal therapies for pleural mesothelioma

Although there is no generally accepted treatment for pleural mesothelioma, most experts agree that survival can be improved significantly when multiple treatments are combined. This is known as multimodal therapy, and scientists are constantly experimenting with surgery, chemotherapy and radiation therapy to discover the most effective combination and timing of these treatments. In an example of a multimodal treatment of pleural mesothelioma, doctors surgery first extrapleural pneumonectomy. Radiation therapy is administered, and to reduce the risk of local recurrence of cancer and eliminate proliferation is prevented by chemotherapy.

The prognosis for mesothelioma

When the process of diagnosis, doctors analyze clinical data on their patients mesothelioma predict the progress and outcome of the disease. This prediction is known as the patient's prognosis.

Previous studies show that the median survival of between four to 18 months, but many factors can significantly affect the prognosis of patients with pleural mesothelioma. The main factors stage of the disease and the general health of the patient. Staging is a system doctors use to describe how mesothelioma has advanced, so early diagnosis gives a better prognosis. And healthy patients who can still perform normal daily tasks tend to better treatment requirements.

Other important prognostic factors include age, gender and smoking habits. Survival is generally better in women, nonsmokers and patients younger than 55 years. Cancer histology, or cellular structure of the tumor can also greatly affect the prognosis. Represents 50 to 70 percent of all cases a subtype called epithelial mesothelioma offers the most optimistic forecast. The epithelial mesothelioma patients respond better to treatment, and other subtypes as sarcomatous and mixed mesothelioma is associated with poorer survival.

Provide patients with an accurate prognosis mesothelioma can be a difficult task for physicians. Not only is the pleural a rare disease, but it is also common for patients diagnosed at an early stage. Since the majority of patients are not eligible for the operation and an operation is necessary for proper staging has survival data for stage I and II has been limited.

Overall about 40 percent of patients with pleural mesothelioma survive one year after diagnosis. About 20 percent survive for two years or more, and 10 percent will be alive five years later. However, it is important to understand that these statistics are based on large sample of patients. Each case is unique, the survival statistics are used as general guidelines.

Patients can work with specialists in the country for the best mesothelioma improve prognosis and discuss treatment to prolong life. Mesothelioma survivor turns into a dynamic treatment plan that combines traditional and alternative medicine to stimulate the forecast.

▷▷▷[pleural mesothelioma] - About Mesothelioma !!

▷▷▷[pleural mesothelioma] - About Mesothelioma !!

What is Cancer?

Firstly, it is important to understand that cancer is not a single disease, there are many different types and mesothelioma is only one kind. Our bodies are made up of tiny building blocks called cells, cancer is a disease of these cells. Cells in different parts of the body look and work differently, and millions of new cells are made ​​every day to replace those lost by age or wear. Throughout the body when new cells are produced in two existing cells divide normally and there is a perfect balance between those who die and those that divide. This vital balance is controlled by a very complicated process if the process control is lost, this can lead to many cells during production, resulting in a tumor. Most tumors are not cancerous (sometimes described as benign) and they remain in the region where they were initially developed. A wart is a common example. The development of cancer involves a change in the quality of the cells and an increased amount. They become more aggressive, destructive and independent normal cells. They are able to invade surrounding tissues, glands and blood vessels and thus spread far from where they began to divide and grow. When the cancer cells reach a new site they may go on dividing and form a new tumor, which is often regarded as secondary or metastatic (secondary).

What is Mesothelioma?

In the United Kingdom, about 2,500 people a year are diagnosed with mesothelioma. It is also known as "diffuse" or "evil" mesothelioma. Mesothelioma is a form of cancer that affects the mesothelium which affects a thin membrane that lines the inner surface of the wall of the chest, where it is known as the pleural and abdominal, which is known as the peritoneum. It is also the organs found within these cavities, such as the heart, lungs and intestines. It is much more common in mesothelioma in the chest than in the abdomen, a case of peritoneal mesothelioma for every 12 cases of pleural mesothelioma.

Pleural Mesothelioma

Pleura comprises two layers: the visceral (innermost) layer is adjacent to the lung and parietal (outer) layer lines the chest wall. The pleura produces the fluid that lubricates the gap between the two layers, which allows the two layers to slide comfortably over each other as we inhale and exhale.

Pleural mesothelioma get the pleura to thicken. This thickening of the pleura by first pressing the lungs or attach to the inside of the chest wall. In both cases, the expansion of the lungs are gradually reduced by the tumor. Fluid, sometimes several liters, can collect between the two layers of the pleura, which affects the lungs' ability to develop and lead to shortness of breath. This is called pleural effusion.

Peritoneal Mesothelioma

Also two inner layers of peritoneum (visceral) layer which is adjacent to the abdominal organs and the outer part (parietal) layer along the abdominal wall. The peritoneal mesothelioma peritoneum to thicken and fluid to collect in the stomach. This collection of fluid called ascites and causes the stomach to swell. Because pleural mesothelioma is more common and often spreads to the abdominal cavity, it is sometimes necessary to determine if pleural mesothelioma is the primary cancer.

▷▷▷[pleural mesothelioma]-Treatment And Pleural Mesothelioma Management

  ▷▷▷[pleural mesothelioma]-Treatment And Pleural Mesothelioma Management

[pleural mesothelioma]-Treatment And Pleural Mesothelioma Management

 Pleural mesothelioma

Pleural mesothelioma is a rare form of cancer is often diagnosed in people who have been exposed to high levels of asbestos. Malignancy affects the pleura, a thin membrane of fat cells that lines the lungs and chest wall. Sometimes it takes 10 years or more for the changes occurring signs of pleural disease, and even good for symptoms occur. These differences may include thickening or calcification of the pleura, a condition often diagnosed as pleural plaques. These Terms of pleural calcification and development of pleural plaques is often a precursor to mesothelioma.


In most cases, pleural disease not fatal, but can cause decreased lung function, and can confirm that a person has suffered significant exposure to asbestos. Those diagnosed with pleural conditions are generally considered a higher risk of developing more serious pleural mesothelioma.

Pleural mesothelioma originates in the pleura, but can quickly spread to the chest wall outside, stomach and heart. Pleural mesothelioma is usually fatal within 1 year after diagnosis. But understanding and recognition of risk factors, such as asbestos, lead to early detection of cancer. Those who are lucky enough to get an early diagnosis may be eligible for vital treatments such as surgical resection of the tumor. This type of treatment can prolong the years of the life of a patient in addition to a typical mesothelioma patient.

Although there is no cure for mesothelioma, treatment options for cancer. There are many ways for the patients to control their disease with a tumor-management, and traditional methods of radiation therapy and chemotherapy, which can relieve the symptoms and making the patient more comfortable. Patients whose diagnosis is made at an early stage of disease, mesothelioma surgery extend survival beyond the levels before the disease being treated.

Treatment and management of tumor

Almost all patients diagnosed with pleural mesothelioma are able to receive some form of treatment for the disease. Although there is currently no cure for mesothelioma, patients have been able to expand the original forecast through schemes advanced mesothelioma treatment, developed in clinics and cancer centers across the United States.

Surgery

At that time, such as tumor and lymph nodes of the body such as the abdominal cavity has metastasized to other areas because of the general surgical resection in patients with pleural mesothelioma are diagnosed at a later stage of the disease is difficult. However, at an early stage diagnosis, surgery can be used to slow the progression of the disease definitely mesothelioma.

Commonly used to treat mesothelioma are surgery, pneumonectomy or extrapleural pneumonectomy. Pneumonectomy is a common method used only in patients with malignant mesothelioma, lung cancer or lung disease is associated with, but also for those who are struggling. Pleurectomy or otherwise removing a portion or all of the affected lung provides patients. Extrapleural pneumonectomy for mesothelioma patients is more convenient and removal of all the affected lung, pleura, diaphragm, and heart cavity around the mesothelial lining of the pericardium, a more comprehensive process.

Chemotherapy

Chemotherapy is probably the most commonly used method of treatment by patients with malignant pleural mesothelioma. Several different chemotherapy drugs are used to varying degrees, although the effectiveness of the management of malignant pleural mesothelioma, a single prescription treatment for the treatment of malignant pleural mesothelioma has been approved by the Food and Drug Administration. Alimta (pemetrexed) in combination with cisplatin combination is currently the only drug approved by the state. However, several clinical studies, the following Gemcitabine, Navelbine, and are trying to determine the effectiveness of other drugs, including onconase.

Radiotherapy

Radiotherapy is used to treat many types of cancer and mesothelioma were not different. Typically, radiation, surgery, chemotherapy, or both together in order to increase the processing speed as a whole can not be used alone to manage cancer. Mutations in tumor cells slow their growth and spread in the body and by using external radiation radiation therapy for pleural mesothelioma.

Alternative and complementary therapies

A more integrative approach to cancer care for the treatment of cancer include a school. Integrative Oncology conventional treatments, not only the above-mentioned uses, but also non-traditional therapies such as acupuncture, massage, reflexology and help patients with pain, anxiety and agitation to manage. Patients with Pleural mesothelioma is actually a comprehensive treatment program they used alternative therapies, such as to improve the efficacy. In general, the difficult side effects of chemotherapy and radiation treatments can tolerate a strong prognosis of patients will be better able to expand. Pleural mesothelioma patients who used alternative therapies were able to do this. However, many of these therapies are preferred, and whether or not they are able to exercise will depend on the patient's health. As with any treatment, the patients before starting an alternative should consult with their oncologist or cancer specialist.

What are the causes of mesothelioma?

Pleural mesothelioma is exposure to asbestos is known to cause only. Asbestos is a naturally occurring mineral and microscopic is used for hundreds of years in a number of different industrial compounds. Asbestos fibers are inserted into the body to throw out once the inner tissue is extremely durable, but also extremely difficult.

On inhalation of asbestos fibers and the outer layers of the pleura of the lung tissue, which lines the chest cavity is deposited in a thin membrane of mesothelial cells. On the surface of these structures provides a special lubrication, because this coating allows the free movement of the body in the body structure. The pleura, like other mesothelial membranes on the surface of a delicate structure and microscopic asbestos fibers can cause pleural plaques. Pleural plaques, pleural mesothelioma tumor cells at the end of turn. In general, the adverse health complications, such as the emergence of fibers of asbestos and a few years until symptoms appear gradually over time, irritation and exacerbate internal tissues are.

Most of those exposed to asbestos asbestos manufacturers successfully injuries and received compensation for diseases such as pleural mesothelioma. If you are unduly exposed to asbestos and asbestos-related health complication if you think fill out the short form on this page. We pleural mesothelioma is exposure to asbestos and mesothelioma, cancer centers, and that you have the best doctors and treatment options for mesothelioma lawyer free information pack promotions, print the details.

Do not let Time Way To Get!

Detection of malignant pleural mesothelioma following exposure to asbestos in the air and do not let stop you from taking legal action in case. Sued for asbestos-related injuries each State shall determine deadlines for filing. These delays also known as the laws of the State of prescription. These measures may be appropriate in order to determine what if any asbestos related disease shortly after the beginning so it is important to consult a legal professional deadlines determined by statute.

▷▷[pleural mesothelioma] - MesotheliomaPleural Malignant pleural mesothelioma

Pleural Mesothelioma

MesotheliomaPleural Malignant pleural mesothelioma, compared with a healthy lung. The most common type of mesothelioma, representing more than two-thirds of all cases. Pleural mesothelioma affects the lining of the chest cavity and the lung known as the pleura.

The pleura is the membrane that surrounds the lungs and chest. The mesothelium, this membrane is known as a few lines body cavities. While the pleura surrounding the lungs, pleural cancer, lung cancer, in fact (which can also be caused by exposure to asbestos) is not.


Such as all kinds of mesothelioma Pleural mesothelioma is difficult to diagnose and can be easily misdiagnosed. If you are already aware of asbestos, mesothelioma symptoms, it is important to tell your doctor so you can be properly diagnosed.

Although the diagnosis of pleural mesothelioma is definitely serious, are not without options. New and original mesothelioma, as well as various available therapies, various clinical trials.

Causes of Pleural Mesothelioma

Mesothelioma is caused by asbestos. Used in a variety of industrial applications and construction, asbestos, small, lightweight, durable and easily in the air.

These fibers are easily inhaled or ingested Once in the air, the size and strong form, they make their way into the lungs and pleura is easy for small passages. Asbestos fibers overcome the body's natural defenses. Asbestos fibers of an unknown chemical reaction or pleural mesothelial cells become abnormal and divide without control caused a sharp shape of a combination of these two factors is not known. Connection, however, between asbestos and mesothelioma has been clear since the early 1960s.

The most important cause of occupational cancer in asbestos US1. In addition to mesothelioma, asbestos lung cancer, mesothelioma, peritoneal mesothelioma, including other forms and the like causes the colon, stomach, larynx and throat cancer associated with some other types of cancer.

In addition, as many absestos asbestos, pleural effusion, pleural thickening, pleural plates (also known as pleural fibrosis), such as is caused by non-cancerous diseases. These conditions, the majority of people do not develop malignant mesothelioma. However, these conditions are associated with increased risk of developing mesothelioma is asbestos exposure levels is considered an important factor to be taken into account.

Pleural Mesothelioma Symptoms

"Do I have mesothelioma?" If you have asked yourself this question, chances are you have a history of asbestos.

Pleural mesothelioma symptoms are not specific and may indicate other, less serious conditions. But if you know you have a history of asbestos exposure, it is wise to be proactive about your health care choices and respecting potential symptoms of pleural mesothelioma. Have regular checkups with your doctor and make sure he or she is aware of your concerns and your history of asbestos exposure.

Pleural mesothelioma is a disease related to dose, which means that the longer and wider your exposure to asbestos, the greater chance you have of developing pleural mesothelioma (or another type of mesothelioma). This dose-dependency can also affect the speed at which you are diagnosed with pleural mesothelioma, although the disease is known for its long latency periods of 10, 20 or even less than 40 years from exposure to disease progression.